Prognostic implication of activated partial thromboplastin time after reteplase or half-dose reteplase plus abciximab: results from the GUSTO-V trial
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چکیده
منابع مشابه
Prognostic implication of activated partial thromboplastin time after reteplase or half-dose reteplase plus abciximab: results from the GUSTO-V trial.
AIMS To evaluate the relationship between activated partial thromboplastin time (aPTT) and clinical outcomes in the Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO-V) trial comparing standard-dose reteplase to half-dose reteplase and abciximab. METHODS AND RESULTS We analysed data on 11,420 patients receiving unfractionated heparin. Peak aPTT levels recorded during the hosp...
متن کاملReteplase plus abciximab and reteplase alone led to similar 30-day mortality rates in acute MI.
P a t i e n t s 16 588 patients who were ≥ 18 years of age (mean age 61 y, 75% men) and had continuous symptoms of chest discomfort for ≥ 30 minutes and < 6 hours from onset to the time of randomization, and electrocardiographic criteria of ST-elevation MI or new left bundle-branch block. Exclusion criteria were planned catheter-based reperfusion; active bleeding or a noncompressible vascular p...
متن کاملFacilitation of early percutaneous coronary intervention after reteplase with or without abciximab in acute myocardial infarction: results from the SPEED (GUSTO-4 Pilot) Trial.
OBJECTIVES We examined the utility of early percutaneous coronary intervention (PCI) in a trial that encouraged its use after thrombolysis and glycoprotein IIb/IIIa inhibition for acute myocardial infarction (MI). BACKGROUND Early PCI has shown no benefit when performed early after thrombolysis alone. METHODS We studied 323 patients (61%) who underwent PCI with planned initial angiography, ...
متن کاملDetermination of Biological Activity of Recombinant Reteplase Using Clot Lysis Time and Activated Partial Thromboplastin Time (APTT) Lysis Methods: A Comparative Study
Recombinant plasminogen activator (reteplase) is a third generation thrombolytic agent which has been used on coronary artery thrombosis and acute myocardial infarction. Clot lysis assay is usually considered as a unique method to evaluate biological activity of reteplase. In this study biological activity of reteplase was determined by APTT (activated partial thromboplastin time) lysis method....
متن کاملDetermination of Biological Activity of Recombinant Reteplase Using Clot Lysis Time and Activated Partial Thromboplastin Time (APTT) Lysis Methods: A Comparative Study
Recombinant plasminogen activator (reteplase) is a third generation thrombolytic agent which has been used on coronary artery thrombosis and acute myocardial infarction. Clot lysis assay is usually considered as a unique method to evaluate biological activity of reteplase. In this study biological activity of reteplase was determined by APTT (activated partial thromboplastin time) lysis method....
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2005
ISSN: 0195-668X,1522-9645
DOI: 10.1093/eurheartj/ehi181